Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8
USERS' SCORE
Good
Based on 54 Reviews
8
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
L-Ornithine (from 1,913 mg L-Ornithine Hydrochloride)
1.5 g (1,500 mg)
**
Top Medical Research Studies
9
We investigated how L-ornithine L-aspartate (LOLA) impacts minimal hepatic encephalopathy (MHE) in patients with cirrhosis. By analyzing six randomized controlled trials with 292 patients, we found that LOLA significantly aids in reversing MHE and prevents the progression to overt hepatic encephalopathy (OHE).
While oral LOLA proved particularly effective, intravenous forms showed similar benefits but were less conclusive. Interestingly, LOLA did not significantly affect mortality or ammonia levels compared to placebo, leading us to conclude that its primary benefits lie in reversing early symptoms.
While oral LOLA proved particularly effective, intravenous forms showed similar benefits but were less conclusive. Interestingly, LOLA did not significantly affect mortality or ammonia levels compared to placebo, leading us to conclude that its primary benefits lie in reversing early symptoms.
Read More
8
We explored how intravenous and oral L-ornithine-L-aspartate (LOLA) affect patients with overt hepatic encephalopathy (HE), a serious complication of chronic liver disease. In a randomized study of 40 patients, we monitored their ammonia levels over five days to see which method worked best.
The results showed significant reductions in ammonia levels for both forms, but no notable difference between the intravenous and oral doses. Ultimately, LOLA proved effective for managing HE, regardless of how it was administered.
The results showed significant reductions in ammonia levels for both forms, but no notable difference between the intravenous and oral doses. Ultimately, LOLA proved effective for managing HE, regardless of how it was administered.
Read More
9
Ornithine aids muscle preservation
We investigated how l ornithine treatment might help in managing liver disease complications like sarcopenia and hepatic encephalopathy. In our study with bile duct-ligated rats, we observed significant benefits, such as reduced hyperammonemia, improved muscle mass, and enhanced muscle protein synthesis. The treatment showed promising results by restoring altered metabolic pathways and signaling mechanisms crucial for muscle health. This suggests that ammonia-reducing therapies like l ornithine could be helpful for patients with chronic liver disease, addressing both brain and muscle complications.
Read More
Most Useful Reviews
9
Alleviated brain fog
45 people found this helpful
Ornithine removes ammonia, greatly easing the liver's workload! Brain fog dissipates, and my productivity, activity, and cheerfulness increase. I take it twice daily, 30 minutes before meals. It has a slightly salty taste that is masked when taken with the sour N-acetylcarnitine. A local product, Hepa Merz, contains similar ornithine but is pricier and unnecessary.
Read More
9
Protective effects
25 people found this helpful
As a replaceable amino acid, L-Ornithine promotes fat burning, especially when combined with Arginine and Carnitine. It possesses antioxidant properties and protects liver cells from toxic influences. I highly recommend this supplement for those seeking to support liver health!
Read More
9
Effective detoxification
23 people found this helpful
I take this supplement to cleanse my liver from toxins. After a week of use, I noticed red spots on my skin indicating toxin release. With continued intake, these spots cleared and other signs of improved liver health became apparent, such as better digestion and stool characteristics. I recommend integrating it with dietary practices that support liver function.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8
- All Researches
9
We examined a case of a 75-year-old man who presented with confusion and fatigue, which were ultimately linked to hyperammonaemic hepatic encephalopathy from an intrahepatic portosystemic shunt. Following a series of inconclusive tests, including brain scans and blood work, his high ammonia levels were identified as the cause of his symptoms.
As part of the treatment, the patient was administered L-ornithine L-aspartate (LOLA) along with other medications. Remarkably, two months later, he reported no further confusion, suggesting that L-ornithine could contribute positively in managing hepatic encephalopathy.
As part of the treatment, the patient was administered L-ornithine L-aspartate (LOLA) along with other medications. Remarkably, two months later, he reported no further confusion, suggesting that L-ornithine could contribute positively in managing hepatic encephalopathy.
Read More
9
Ornithine aids muscle preservation
We investigated how l ornithine treatment might help in managing liver disease complications like sarcopenia and hepatic encephalopathy. In our study with bile duct-ligated rats, we observed significant benefits, such as reduced hyperammonemia, improved muscle mass, and enhanced muscle protein synthesis. The treatment showed promising results by restoring altered metabolic pathways and signaling mechanisms crucial for muscle health. This suggests that ammonia-reducing therapies like l ornithine could be helpful for patients with chronic liver disease, addressing both brain and muscle complications.
Read More
9
Ornithine aspartate's potential benefits
We explored the effects of ornithine aspartate and vitamin E on metabolic dysfunction associated with steatotic liver disease. In a study involving adult Sprague-Dawley rats, groups were treated for 28 weeks, with some receiving a high-fat diet and daily doses of ornithine aspartate.
We observed that ornithine aspartate significantly reduced collagen buildup and improved biochemical markers of liver stress. It also enhanced energy production and thyroid hormone metabolism, suggesting potential benefits for tackling fatty liver disease.
Overall, these findings indicate that ornithine aspartate might be a promising addition to treatments for metabolic liver conditions.
We observed that ornithine aspartate significantly reduced collagen buildup and improved biochemical markers of liver stress. It also enhanced energy production and thyroid hormone metabolism, suggesting potential benefits for tackling fatty liver disease.
Overall, these findings indicate that ornithine aspartate might be a promising addition to treatments for metabolic liver conditions.
Read More
9
Our exploration focused on l-ornithine-l-aspartate (LOLA) and its potential impact on non-alcoholic fatty liver disease (NAFLD). Using models of liver conditions, we observed that LOLA helped reduce toxic ammonium levels and positively influenced the expression of important genes linked to energy metabolism and fatty acid transport.
Although these findings are promising, more substantial clinical trials are needed to confirm LOLA's effectiveness as a treatment for NAFLD. Ultimately, LOLA shows potential to improve metabolic dysfunctions associated with liver disease.
Although these findings are promising, more substantial clinical trials are needed to confirm LOLA's effectiveness as a treatment for NAFLD. Ultimately, LOLA shows potential to improve metabolic dysfunctions associated with liver disease.
Read More
9
We investigated how L-ornithine L-aspartate (LOLA) impacts minimal hepatic encephalopathy (MHE) in patients with cirrhosis. By analyzing six randomized controlled trials with 292 patients, we found that LOLA significantly aids in reversing MHE and prevents the progression to overt hepatic encephalopathy (OHE).
While oral LOLA proved particularly effective, intravenous forms showed similar benefits but were less conclusive. Interestingly, LOLA did not significantly affect mortality or ammonia levels compared to placebo, leading us to conclude that its primary benefits lie in reversing early symptoms.
While oral LOLA proved particularly effective, intravenous forms showed similar benefits but were less conclusive. Interestingly, LOLA did not significantly affect mortality or ammonia levels compared to placebo, leading us to conclude that its primary benefits lie in reversing early symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 54 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Alleviated brain fog
45 people found this helpful
Ornithine removes ammonia, greatly easing the liver's workload! Brain fog dissipates, and my productivity, activity, and cheerfulness increase. I take it twice daily, 30 minutes before meals. It has a slightly salty taste that is masked when taken with the sour N-acetylcarnitine. A local product, Hepa Merz, contains similar ornithine but is pricier and unnecessary.
Read More
9
Protective effects
25 people found this helpful
As a replaceable amino acid, L-Ornithine promotes fat burning, especially when combined with Arginine and Carnitine. It possesses antioxidant properties and protects liver cells from toxic influences. I highly recommend this supplement for those seeking to support liver health!
Read More
9
Effective detoxification
23 people found this helpful
I take this supplement to cleanse my liver from toxins. After a week of use, I noticed red spots on my skin indicating toxin release. With continued intake, these spots cleared and other signs of improved liver health became apparent, such as better digestion and stool characteristics. I recommend integrating it with dietary practices that support liver function.
Read More
9
Detoxification benefits
10 people found this helpful
This effectively reduces discomfort from heavy workouts and enhances restful sleep during detox. It alleviates die-off symptoms when purging parasites and quickly helps with brain fog. I've followed the instructions to take it on an empty stomach for better absorption and will repurchase for future cleanses.
Read More
9
Reduced ammonia smell
9 people found this helpful
My husband occasionally sweats with an ammonia-like smell due to liver dysfunction. If the liver cannot process ammonia, it enters the bloodstream and is expelled through sweat. Ornithine transforms ammonia into non-toxic urea via the ornithine cycle, effectively eliminating the smell.
Read More
Frequently Asked Questions
7.5
Body odour improvement
18 people found this helpful
I developed hyperhidrosis in middle age, exacerbated by the heat wave. My sweat had an unpleasant ammonia smell, likely due to weak liver function. Upon starting Ornithine, the odour vanished completely by the third day. I believe my body’s ammonia was linked to liver issues.
9
Effective detoxification
23 people found this helpful
I take this supplement to cleanse my liver from toxins. After a week of use, I noticed red spots on my skin indicating toxin release. With continued intake, these spots cleared and other signs of improved liver health became apparent, such as better digestion and stool characteristics. I recommend integrating it with dietary practices that support liver function.
7
Improved liver function
8 people found this helpful
Used to enhance liver function. I was somewhat concerned about my liver function levels from a blood test, so I started this supplement alongside Milk Thistle. After a few months, my latest blood tests showed an improvement, confirming I felt the effects. I intend to keep taking it.
7.5
Certain effects on liver
12 people found this helpful
There was a concern regarding my liver health due to blood test results, so I began exercising and dieting. Initially, I felt heavy and dull, but after starting intake, I noticed my body feeling lighter from the third week, and my energy levels, including my waking clarity, significantly improved.
9
Alleviated brain fog
45 people found this helpful
Ornithine removes ammonia, greatly easing the liver's workload! Brain fog dissipates, and my productivity, activity, and cheerfulness increase. I take it twice daily, 30 minutes before meals. It has a slightly salty taste that is masked when taken with the sour N-acetylcarnitine. A local product, Hepa Merz, contains similar ornithine but is pricier and unnecessary.
9
Reduced ammonia smell
9 people found this helpful
My husband occasionally sweats with an ammonia-like smell due to liver dysfunction. If the liver cannot process ammonia, it enters the bloodstream and is expelled through sweat. Ornithine transforms ammonia into non-toxic urea via the ornithine cycle, effectively eliminating the smell.
9
Protective effects
25 people found this helpful
As a replaceable amino acid, L-Ornithine promotes fat burning, especially when combined with Arginine and Carnitine. It possesses antioxidant properties and protects liver cells from toxic influences. I highly recommend this supplement for those seeking to support liver health!
8.5
Ammonia reduction
5 people found this helpful
Excellent as an aid for liver support during antiparasitic treatment and for lowering ammonia in the bloodstream! I really like it!
7.5
Reduced nighttime urination
22 people found this helpful
I started taking it to detoxify the liver from ammonia. Initially, I took one before bed, but now I combine it with one GABA 500mg. My tiredness recovered quickly, and the number of nighttime visits to the toilet significantly decreased. For those experiencing 3-4 trips to the loo at night, it's worth a try.
9
Improves fatty liver
1 people found this helpful
After starting ornithine, my yearly blood tests show improvement in my fatty liver condition.
7
We explored hepatic encephalopathy (HE), a serious complication of liver disease that affects brain function. This condition can be covert or overt, and it often arises from high ammonia levels due to liver dysfunction.
Recent studies highlighted the role of inflammatory processes and disruptions in gut health in worsening HE. Among various treatments, L-ornithine L-aspartate (LOLA) stands out as it helps lower ammonia levels by enhancing the urea cycle. However, while LOLA has shown potential, further investigation is needed to confirm its benefits. Ultimately, managing HE may also involve lifestyle modifications and, in severe cases, transplantation.
Recent studies highlighted the role of inflammatory processes and disruptions in gut health in worsening HE. Among various treatments, L-ornithine L-aspartate (LOLA) stands out as it helps lower ammonia levels by enhancing the urea cycle. However, while LOLA has shown potential, further investigation is needed to confirm its benefits. Ultimately, managing HE may also involve lifestyle modifications and, in severe cases, transplantation.
9
We examined a case of a 75-year-old man who presented with confusion and fatigue, which were ultimately linked to hyperammonaemic hepatic encephalopathy from an intrahepatic portosystemic shunt. Following a series of inconclusive tests, including brain scans and blood work, his high ammonia levels were identified as the cause of his symptoms.
As part of the treatment, the patient was administered L-ornithine L-aspartate (LOLA) along with other medications. Remarkably, two months later, he reported no further confusion, suggesting that L-ornithine could contribute positively in managing hepatic encephalopathy.
As part of the treatment, the patient was administered L-ornithine L-aspartate (LOLA) along with other medications. Remarkably, two months later, he reported no further confusion, suggesting that L-ornithine could contribute positively in managing hepatic encephalopathy.
9
Our exploration focused on l-ornithine-l-aspartate (LOLA) and its potential impact on non-alcoholic fatty liver disease (NAFLD). Using models of liver conditions, we observed that LOLA helped reduce toxic ammonium levels and positively influenced the expression of important genes linked to energy metabolism and fatty acid transport.
Although these findings are promising, more substantial clinical trials are needed to confirm LOLA's effectiveness as a treatment for NAFLD. Ultimately, LOLA shows potential to improve metabolic dysfunctions associated with liver disease.
Although these findings are promising, more substantial clinical trials are needed to confirm LOLA's effectiveness as a treatment for NAFLD. Ultimately, LOLA shows potential to improve metabolic dysfunctions associated with liver disease.
9
We investigated how L-ornithine L-aspartate (LOLA) impacts minimal hepatic encephalopathy (MHE) in patients with cirrhosis. By analyzing six randomized controlled trials with 292 patients, we found that LOLA significantly aids in reversing MHE and prevents the progression to overt hepatic encephalopathy (OHE).
While oral LOLA proved particularly effective, intravenous forms showed similar benefits but were less conclusive. Interestingly, LOLA did not significantly affect mortality or ammonia levels compared to placebo, leading us to conclude that its primary benefits lie in reversing early symptoms.
While oral LOLA proved particularly effective, intravenous forms showed similar benefits but were less conclusive. Interestingly, LOLA did not significantly affect mortality or ammonia levels compared to placebo, leading us to conclude that its primary benefits lie in reversing early symptoms.
References
- Sen BK, Pan K, Chakravarty A. Hepatic Encephalopathy: Current Thoughts on Pathophysiology and Management. Curr Neurol Neurosci Rep. 2025;25:28. doi:10.1007/s11910-025-01415-9
- Yousif M, McCluskey P, Magee C, Ntlholang O. Unusual Presentation of Confusion: Hyperammonaemic Hepatic Encephalopathy Due to Intrahepatic Portosystemic Venous Shunt. Ir Med J. 2025;118:11.
- Bosoi CR, Kumar A, Oliveira MM, Welch N, Clément MA, et al. Attenuating hyperammonemia preserves protein synthesis and muscle mass via restoration of perturbed metabolic pathways in bile duct-ligated rats. Metab Brain Dis. 2025;40:110. doi:10.1007/s11011-024-01525-2
- [Guidelines for diagnosis and management of drug-induced liver injury caused by anti-tuberculosis drugs (2024 version)]. Zhonghua Jie He He Hu Xi Za Zhi. 2024;47:1069. doi:10.3760/cma.j.cn112147-20240614-00338
- Longo L, Marschner RA, de Freitas LBR, de Bona LR, Behrens L, et al. Redefining the Role of Ornithine Aspartate and Vitamin E in Metabolic-Dysfunction-Associated Steatotic Liver Disease through Its Biochemical Properties. Int J Mol Sci. 2024;25. doi:10.3390/ijms25136839
- Jhajharia A, Singh S, Jana S, Ashdhir P, Nijhawan S. Intravenous versus oral 'L-ornithine-L-aspartate' in overt hepatic encephalopathy: a randomized comparative study. Sci Rep. 2024;14:11862. doi:10.1038/s41598-024-62293-8
- Canbay A, Götze O, Kucukoglu O, Weinert S, Croner RS, et al. l-Ornithine-l-Aspartate (LOLA) Normalizes Metabolic Parameters in Models of Steatosis, Insulin Resistance and Metabolic Syndrome. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040506
- He Q, Mao C, Chen Z, Zeng Y, Deng Y, et al. Efficacy of L-ornithine L-aspartate for minimal hepatic encephalopathy in patients with cirrhosis: A meta-analysis of randomized controlled trials. Arab J Gastroenterol. 2024;25:84. doi:10.1016/j.ajg.2024.01.006
- Ivchenko GS, Lobzhanidze NN, Rusina DS, Denisova EV, Ivchenko AA. [Mild post-COVID syndrome in young patients]. Ter Arkh. 2023;95:674. doi:10.26442/00403660.2023.08.202349
